The effect of the choice of maternal age-specific prevalence curve on the model predicted Down syndrome detection rate was examined. All 19 published regression curves from 11 birth prevalence series in four meta-analyses were included. The detection rate for a five per cent false-positive rate was
Maternal age-specific rates of Down syndrome used in serum screening are biased low
โ Scribed by Ernest B. Hook
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 33 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0197-3851
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๐ SIMILAR VOLUMES
This study is a novel approach in establishing the maternal age-specific risk for Down syndrome screening in an Asian population. The relative frequency by one-year maternal age interval in women who had live births in the Taiwan area between 1975 and 1995 was used as the age-specific distribution o
Background: maternal age-specific rates of Down syndrome livebirths are widely utilized in personal and policy decisions concerning provision of and election of prenatal cytogenetic diagnostic services. The only extensive reference data available are on those of primarily European ancestral origin.
High free beta human chorionic gonadotropin ( -hCG) and low alpha-fetoprotein (AFP) levels were found in 47 Asian Down's syndrome pregnancies (median values 2โข79 and 0โข77 MOM, respectively). At a 5 per cent false-positive rate, free -hCG alone would identify 46โข8 per cent of Down's syndrome pregnanc
Precision and accuracy in determining rates of Down syndrome at livebirth are indispensible to algorithms which determine eligibility for prenatal cytogenetic diagnostic services. W e derived Down syndrome rates by single year of maternal age which we propose as a revised rate schedule for backgroun