Materials and coatings based on biopolymer-apatite nanocomposites: obtaining, structural characterization and in-vivo tests
✍ Scribed by L. Sukhodub
- Book ID
- 102504105
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 385 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0933-5137
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✦ Synopsis
Abstract
Present paper discusses the results obtained for three different nanocomposite systems, namely chitosan‐apatite, hydrogel‐HA and collagen‐apatite coatings onto Ti~6~Al~4~V substrates. Common analytical techniques such as X‐ray diffraction analysis, infrared spectroscopy, scanning electron microscopy with X‐ray dispersive energy analysis were employed to characterize the resulting materials. Special attention was given to the in‐vivo tests of the obtained chitosan‐apatite composites using 48 linear laboratory rats at the age of 4 months. Using energy dispersive X‐ray analysis (EDX) of HA nanoclusters, formed in hydrogel nanoreactor matrixes, the process of their formation depending on monomer nature and ratio, as well as on their consistent state was optimized. In case of microgranules based on homopolyacrylamide gel we observed almost ideal coincidence on the stochiometric composition with pure HA (Ca/P=1.67). Thermal substrate method recently proposed to obtain hydroxyapatite coating on titanium was used for high crystallinity hydroxyapatite deposition onto titanium‐based plate (TiAlV) at the physiological temperature. The coating was produced onto clear plates and onto collagen covered surfaces. The best pH value for depositing of the high crystallinity hydroxyapatite on a target was pH 6,15. Depositing speed was decreased with pH decreasing, and while pH value was increased up to 6,3 crystallinity was going down. Collagen has improved both the speed and the crystallinity of the deposited layers.