𝔖 Bobbio Scriptorium
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Mast cells and tumor angiogenesis

✍ Scribed by David A. Kessler; Robert S. Langer; Naomi A. Pless; Judah Folkman

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
711 KB
Volume
18
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2–3 days after implantation. A 40‐fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague‐Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.

πŸ“œ SIMILAR VOLUMES

Mast cells and tumor angiogenesis
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✍ David A. Kessler; Robert S. Langer; Naomi A. Pless; Judah Folkman πŸ“‚ Article πŸ“… 1976 πŸ› John Wiley and Sons 🌐 French βš– 711 KB
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## Abstract There is much evidence that angiogenesis is related to mast cells. Mast cells accumulate in many angiogenesis‐dependent situations, including tumor growth, rheumatoid arthritis, ovulation, would healing, and tissue repair. Several mast cell mediators are angiogenic and regulate endothel