Mast cell heterogeneity in man: unique functional properties of skin mast cells in response to a range of polycationic stimuli

Mast cells migrate, but do not degranula

Mast cells migrate, but do not degranulate, in response to fractalkine, a membrane-bound chemokine expressed constitutively in diverse cells of the skin

✍ Elektra J. Papadopoulos; David J. Fitzhugh; Christine Tkaczyk; Alasdair M. Gilfi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 338 KB 👁 1 views

Mast cells (MC) are anatomically located near nerves and blood vessels in skin and the gastrointestinal tract and tend to localize within certain cutaneous tumors such as neurofibromas. However, the molecular mechanisms by which MC home to these sites are not well characterized. Fractalkine (FK) is