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Mast cell activation involves plasma membrane potential- and thapsigargin-sensitive intracellular calcium pools

✍ Scribed by O. Kassel; Y. Amrani; Y. Landry; C. Bronner

Book ID
115274143
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
701 KB
Volume
9
Category
Article
ISSN
0767-3981

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## Abstract The human mast cell line (HMC‐1) has been used to study the relationship between intracellular pH and cytosolic calcium (Ca^2+^) in mast cells. Thapsigargin (TG) caused store‐operated Ca^2+^ entry, that is enhanced by the PKC activator PMA. NH~4~Cl‐induced alkalinization showed an inhib