A new series of thymine derivative acyclic nucleosides, with mono-or polyfluorosubstitution on the acyclic portion of the molecules have been studied by fast-atom bombardment mass spectrometry, with the aid of metastable ion studies and deuterium labelling experiments. The protonated molecules show
Mass spectrometry of some permethylated apiosyl nucleosides
โ Scribed by Richard M. Thompson; Dilipkumar K. Parikh; Ronald R. Watson
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 249 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1076-5174
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โฆ Synopsis
The mass spectra of the germethyl derivatives of a group of synthetic D-apio-L-furanosyl nucleosides were collected and compared with those of their ribosyl analogs. While most of the m/e values are the same between analogous spectra, some of the relative intensities differ markedly. Each spectrum contains characteristic ions which are probably due to fragmentation of the dissimilar sugar moieties.
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๐ SIMILAR VOLUMES
Folic acid and several analogs have been characterized as their permethylated derivatives. These derivatives are readily evaporated from the solid probe and provide spectra with abundant molecular ions and characteristic fragment ions. This method has been used to confirm the identities of the two m