This article describes the use of two mass spectrometric techniques, matrix-assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI) mass spectrometry, toward a variety of challenging problems in drug discovery and identification. Quantitative ESI was used to screen for inhibit
Mass spectrometry in combinatorial chemistry
โ Scribed by Christine Enjalbal; Jean Martinez; Jean-Louis Aubagnac
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 402 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0277-7037
No coin nor oath required. For personal study only.
โฆ Synopsis
component identiยฎcation and quantiยฎcation. In this respect, mass spectrometry has been found to be the method of choice, providing rapid, sensitive, and informative analyses, especially when coupled to chromatographic separation. Fully automated workstations able to cope with several hundreds of compounds per day have been designed.
After a brief introduction to describe the combinatorial approach, library characterization will be discussed in detail, considering ยฎrst the solution-based methodologies and secondly the support-bound material analyses.
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