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Mass spectrometry-based proteomics in reproductive medicine

✍ Scribed by Aggeliki Kolialexi; Ariadni Mavrou; George Spyrou; George Th. Tsangaris

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
263 KB
Volume
27
Category
Article
ISSN
0277-7037

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✦ Synopsis

Abstract

The emergence of powerful mass spectrometry‐based proteomic techniques has added a new dimension to the field of biomedical research. Application of these high throughput methodologies in pregnancy‐related pathology has contributed to the comprehension of the underlying pathophysiologies and the successful identification of relevant protein biomarkers that can potentially change early diagnosis and treatment of several medical conditions related to human pregnancy. Most of the existing research on human reproduction and gestation has focused on follicular fluid, cervical/vaginal fluid, and amniotic fluid. Although proteome technologies in reproductive medicine research are not as yet widely applied, characterization of the proteome of reproductive fluids can be expected to significantly improve maternal healthcare. This article aims to summarize the applications of mass spectrometry based technology on the most important and specific biological fluids related to reproduction and gestation. Β© 2008 Wiley Periodicals, Inc., Mass Spec Rev 27: 624–634, 2008

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