Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane- 2-thiols—precursors and degradation products of chemical warfare agents
✍ Scribed by Barbora Papoušková; Petr Bednář; Jakub Stýskala; Jan Hlaváč; Petr Barták; Karel Lemr
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 244 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1076-5174
- DOI
- 10.1002/jms.1674
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✦ Synopsis
Abstract
N,N‐dialkylaminoethane‐2‐thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization‐multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of ‐S‐S‐ linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new µLC/MS method, based on ion‐pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion‐pairing agent to increase the low retention of compounds of interest in the reverse‐phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides. Copyright © 2009 John Wiley & Sons, Ltd.