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Mass spectrometric techniques for structure and novelty determination of kirromycin-like antibiotics

✍ Scribed by D. M. F. Edwards; E. Selva; S. Stella; L. F. Zerilli; G. G. Gallo

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 534 KB
Volume: 21
Category: Article
ISSN: 1076-5174
DOI: 10.1002/bms.1200210110

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✦ Synopsis

Direct liquid introduction negative ion mass spectra have been studied for some kirromycin class antibiotics. A scheme for the interpretation of the mass sju!&al fragmentation patterns is presented and shown to be useful for structure elucidation and novelty determination. Since these spectra are obtained by liquid chromatography/mass spectrometry, antibiotic isolates need not be highly purified. However, where pure preparations are available confirmation of molecular weight assignments may be obtained with fast atom bombardment ionization.

a macromolecule which assists in peptide chain elongation. The specific mechanism of action of kirromycin has been studied in Literature reports of related antibiotics continue to appear5-' and the more general name 'ELFbYcin' is often used to d e ~r i b e antibiotics which bind EFTu in a way similar to kirromycin.

EFTu interaction is used as a target criterion for the

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