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Mass spectrometric analysis of novel phosphorylation sites in the TRPC4β channel

✍ Scribed by Ji Eun Lee; Min-Young Song; Seok Kyo Shin; Seong Han Bae; Kang-Sik Park

Book ID
112185908
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
654 KB
Volume
26
Category
Article
ISSN
0951-4198

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Interferon regulatory factor 3 (IRF-3) is a critical transcription factor that regulates innate immune responses against viral infection. Upon infection, IRF-3 is activated through phosphorylation of Ser/Thr residues in its C-terminal domain by the kinases, IKK-i and/or TBK-1. This phosphorylation t