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Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography

✍ Scribed by Başak Kükrer; Vasco Filipe; Esther van Duijn; Piotr T. Kasper; Rob J. Vreeken; Albert J. R. Heck; Wim Jiskoot

Book ID
106494042
Publisher
Springer US
Year
2010
Tongue
English
Weight
319 KB
Volume
27
Category
Article
ISSN
0724-8741

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✍ John P. Gabrielson; Mark L. Brader; Allen H. Pekar; Kathrin B. Mathis; Gerhard W 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 167 KB

Size-exclusion high-performance liquid chromatography (SE-HPLC, SEC) is the long-standing biopharmaceutical industry standard for quantitation of soluble protein aggregates. Recently, sedimentation velocity analytical ultracentrifugation (SV-AUC) has emerged as a possible orthogonal technique to SEC