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Mass spectrometric analysis of histone posttranslational modifications

✍ Scribed by A.L. Burlingame; Xin Zhang; Robert J. Chalkley


Book ID
116986568
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
938 KB
Volume
36
Category
Article
ISSN
1046-2023

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## Abstract Histones typically play a role in DNA packaging and transcription regulation. These proteins are heavily modified by acetylation, methylation, phosphorylation and/or ubiquitination, and various combinations of these modifications alter histone functions and form the basis of the histone