Mass spectra and three-dimensional structures of γ-N-aryl(alkyl)aminopiperidines

✍ Scribed by E. E. Stashenko; P. I. Zakharov; V. V. Kuznetsov; L. A. Gaivoronskaya; B. S. Subbotin; N. S. Prostakov

• Book ID: 104781975
• Publisher: Springer US
• Year: 1988
• Tongue: English
• Weight: 402 KB
• Volume: 24
• Category: Article
• ISSN: 0009-3122
• DOI: 10.1007/bf00475604

✦ Synopsis

The fragmentation of the investigated compounds proceeds with both retention and cleavage of the piperidine ring and makes it possible to distinguish the spatial orientation of the methyl group in the C(~) position of the ring in the analysis of the geometrical isomers of this series.

Compounds with high specific physiological activity have been found among N-substituted y-aminopiperidines.

Some of them are used as medicinal preparations [i]. We have accomplished the mass-spectrometric analysis of I-XI, which were described in [2, 3]. Compounds I-VIII were studied in the form of mixtures of two geometrical isomers, while y-aminopiperidines, cis-IX-cis-Xl and trans-IX-trans-Xl were the individual cis and trans isomers, the structures of which were previously established [4]. The 1,2e,5a-trimethyl-4e-arylaminopiperidines are the cis isomers, while the 1,2e-5e,-trimethyl-4e-arylaminopiperidines are the trans isomers.