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Mass-correlated Delayed Extraction in Linear Time-of-Flight Mass Spectrometers

✍ Scribed by S.V. Kovtoun

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
323 KB
Volume
11
Category
Article
ISSN
0951-4198

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✦ Synopsis

Theoretical analysis and model calculations were directed to find a means of extending the Wiley-McLarens principles of velocity focusing to wide range mass spectra. Both the cases of time-profiled single-field and double-field operation modes were considered. High mass accuracy over about a 10-fold ratio of masses at high (M 0 ) and low (m 0 ) ends of spectrum is attainable with a single-field ion source in the case of matrix-assisted laser desorption ionization (MALDI). This range ratio increases by a factor of 10 using the double-field operation mode. In the latter case, mass resolution increases at least by a factor of 7 compared with the standard delayed extraction mode in typical MALDI conditions. Application to a combined single-field/double-field operation mode enables the maintenance of accuracy parameters over a mass ratio M 0 /m 0 of about 1000.

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