Mass changes of inositol(1,4,5) trisphosphate in trachealis muscle following agonist stimulation
β Scribed by Edwin R. Chilvers; R.A. John Challiss; Peter J. Barnes; Stafan R. Nahorski
- Book ID
- 115882305
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 313 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0014-2999
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Human normal (RCMH) and Duchenne muscular dystrophy (RCDMD) cell lines, as well as newly developed normal and dystrophic murine cell lines, were used for the study of both changes in inositol 1,4,5trisphosphate (IP 3 ) mass and IP 3 binding to receptors. Basal levels of IP 3 were increased two-to th
Inositol-1,4,5-trisphosphate (IP3) has been proposed to be a second messenger in response to alpha-l-adrenoceptor stimulation also in myocardial cells. We studied the effect of alpha-l-adrenoceptor stimulation (5 x 10 -5 tool/1 phenylephrine or 5 x 10 -5 mol/1 noradrenaline both in the presence of 1