๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Marrow transplantation for children with acute nonlymphoblastic leukemia in first remission

โœ Scribed by Sanders, Jean E. ;Thomas, E. Donnall ;,

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
303 KB
Volume
9
Category
Article
ISSN
0098-1532

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โœฆ Synopsis

Abstract

Thirteen children between the ages of two and 17 years with acute nonlymphoblastic leukemia in first remission were transplanted from HLA matched sibling donors. They were transplanted at a median of four months [2โ€“8] following diagnosis. The preparative regimen of cyclophosphamide and total body irradiation was well tolerated. Two patients died of pneumonia 66 and 94 days following transplant. One patient relapsed at 431 days, and died of leukemia at 490 days. Ten are living in remission 20โ€“53 months following transplantation. None are on maintenance chemotherapy, and all lead normal lives. As yet, growth is not impaired.

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To the Editor: Relapse is still a problem for leukemias, particularly in the autologous bone marrow transplantation (ABMT) setting. Moreover, the CD20 positive phenotype, deยฎned as >20% expression, may be associated with a worse outcome [1]. Therefore, our experience with such a patient in whom we a