HLA class I antigens of the human major histocompatibility complex (MHC) play an important role in immune response. Consistent with their role in immune surveillance, these antigens are expressed on most cell types. However, a marked deficiency or lack of expression of these antigens has been observ
Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines
β Scribed by Dharam P. Singal; Ming Ye; Jin Ni; Denis P. Snider
- Book ID
- 107908629
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 679 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0165-2478
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HLA class I molecules present antigenic peptides to cytotoxic T lymphocytes and thus play an important role in immune surveillance of cells infected with virus or altered by malignant transformation. Immunochemical studies have demonstrated a marked deficiency or lack of expression of class I molecu
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