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Marked differences in the prevalence of chloroquine resistance between urban and rural communities in Burkina Faso

✍ Scribed by Peter E. Meissner; Germain Mandi; Frank P. Mockenhaupt; Steffen Witte; Boubacar Coulibaly; Ulrich Mansmann; Claudia Frey; Heiko Merkle; Juergen Burhenne; Ingeborg Walter-Sack; Olaf Müller


Book ID
116182014
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
388 KB
Volume
105
Category
Article
ISSN
0001-706X

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The relationship between Pfcrt T76 and Pfmdr-1 Y86 mutations in Plasmodium falciparum was explored in samples from patients with uncomplicated malaria and tested in vitro and in vivo with chloroquine (CQ) in Burkina Faso. The two mutations were strongly related. The Pfcrt T76 mutation was found in 8