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Polyubiquitylation of PARP-1 through ubi

Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides

✍ Tao Wang; Cynthia M. Simbulan-Rosenthal; Mark E. Smulson; P. Boon Chock; David C 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB

## Abstract Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is the most abundant and the best‐studied isoform of a family of enzymes that catalyze the polymerization of ADP‐ribose from NAD^+^ onto target proteins. PARP‐1 is well known to involve in DNA repair, genomic stability maintenance, transcription re