Marine natural products XIV. 1-S-bromo-4-R-hydroxyselin-7-ene, a metabolite of the marine alga Laurencia sp.

✍ Scribed by Allan F. Rose; James J. Sims

• Book ID: 104235418
• Publisher: Elsevier Science
• Year: 1977
• Tongue: French
• Weight: 196 KB
• Volume: 18
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)83118-x

✦ Synopsis

Investigations of marine red algae of the genus Luurencia have led to the isolation of a number of halogenated terpenes.' Continuation of our interest in tiaurencia 6~. from Australia has led to the isolation of a new brominated sesquiterpene (+)-1-S-bromo-4-R-hydroxyselin-7-ene, 2. Hexane extraction of the air dried alga, which was collected in Guerilla Bay, New South Wales, Australia, gave a dark green extract. Open column chromatography of the extract on silica gel n gave, in addition to two previously unreported Cl5 eneyne compounds and elatol,L fraction A. High pressure liquid chromatography (Bio-Sil A, 8% ethyl acetate in hexanes, recycle mode) gave pure 2, 42 mg (0.005%) as a viscous oil, [a], +54.4" (c 1.35, CHC13).

x 5 2