Mapping the α-globin genes in HB J Mexico carriers

✍ Scribed by G. Trabuchet; F. Morle; G. Verdier; Jacqueline Godet; M. Benabadji; V. M. Nigon

• Book ID: 104703065
• Publisher: Springer
• Year: 1982
• Tongue: English
• Weight: 406 KB
• Volume: 62
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00282308

✦ Synopsis

The organization of the alpha-globin genes was studied by restriction endonuclease mapping, in subjects carrying the alpha variant Hb J Mexico. A subject homozygous for Hb J synthesized both Hb J (about 55%) and Hb A and had two alpha loci per chromosome. His restriction site map was found to be identical to that obtained with a normal DNA, except for a mutant Bgl II site which was observed on the Hb J chromosome proximal to the 5' alpha-locus. We have also mapped the DNA of a compound heterozygote for Hb J and alpha-thalassemia, who synthesizes 38% Hb J and we have found a single alpha gene corresponding to a - alpha 3.7 haplotype on one chromosome and two alpha genes, respectively alpha J and alpha A, on the other.