Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells

The subnuclear organization of histone g

The subnuclear organization of histone gene regulatory proteins and 3′ end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types

✍ Prachi N. Ghule; Zbigniew Dominski; Jane B. Lian; Janet L. Stein; Andre J. van W 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB 👁 1 views

## Abstract Human histone gene expression is controlled at the level of transcription initiation and subsequent 3′end processing to generate non‐polyadenylated stem‐loop containing histone mRNAs. Transcription is controlled at the G1/S phase transition by the Cyclin E/CDK2 mediated induction of p22