Mapping the gene for X-linked lymphoproliferative disease
β Scribed by Frederick Hecht
- Book ID
- 119104563
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 111 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0165-4608
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The abnormal gene in X-linked lymphoproliferative syndrome John L Sullivan The gene defect responsible for X-linked lymphoproliferative syndrome, SH2DlA (SH2-domain-containing gene 7A), was recently cloned. This gene encodes a small protein of 128 amino acids containing a single SH2 domain, which is
## Abstract A family study was performed in order to diagnose Xβlinked lymphoproliferative (XLP) disease in a fetus. The molecular genetic analysis indicated that the fetus, as well as its healthy 7βyearβold brother, inherited XLP. Analysis of immunoglobulin subclasses from the 7βyearβold brother s