Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25–p26 and to mouse Chromosome 6 close to theRaf-1locus with polymorphic tandem repeat sequences
✍ Scribed by Chaim O. Jacob; Kirk Mykytyn; Terry Varcony; Harry A. Drabkin
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 660 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0938-8990
No coin nor oath required. For personal study only.
✦ Synopsis
Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.