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Mapping of the Interaction Interface of DNA Polymerase β with XRCC1

✍ Scribed by Michael R. Gryk; Assen Marintchev; Mark W. Maciejewski; Anthony Robertson; Samuel H. Wilson; Gregory P. Mullen


Book ID
114329194
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
873 KB
Volume
10
Category
Article
ISSN
0969-2126

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## Abstract We investigated the physical association of the DNA topoisomerase IIβ binding protein 1 (TopBP1), involved in DNA replication and repair but also in regulation of apoptosis, with poly(ADP‐ribose) polymerase‐1 (PARP‐1). This enzyme plays a crucial role in DNA repair and interacts with ma