✦ LIBER ✦
Mapping of the highest occupied molecular orbital of a DNA–RNA hybrid by cobalt–benzoyl peroxide oxidation
✍ Scribed by Takashi Nakamura; Isao Saito
- Book ID
- 104210931
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 122 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Ab initio calculations of the highest occupied molecular orbital (HOMO) of the guanine (G)-containing sequences with DNA-RNA hybrid geometry were performed at the HF 6-31G* level. Sequence dependent guanine oxidation with Co(II) and benzoyl peroxide (BPO) has been observed for a DNA-RNA hybrid as revealed by PAGE analysis of the reaction mixture after hot piperidine treatment. The DNA cleavage of 5%-GGG-3% sequence was consistent with the selectivity predicted from calculated HOMOs of 5%-GGG-3% sequence.