Partial rescue of the ocular retardation
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Bone-Larson, Cynthia ;Basu, Sharmila ;Radel, Jeffrey D. ;Liang, Meiying ;Perozek
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Article
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2000
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John Wiley and Sons
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English
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The or J allele of the murine ocular retardation mutation is caused by a premature stop codon in the homeodomain of the Chx10 gene. When expressed on an inbred 129/Sv strain, the or J phenotype is characterized by microphthalmia and a thin, poorly differentiated retina in which the peripheral portio