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Mapping of central dopamine synthesis in man, using positron emission tomography withl-[β-11C]DOPA

✍ Scribed by Hiroshi Ito; Miho Shidahara; Harumasa Takano; Hidehiko Takahashi; Shoko Nozaki; Tetsuya Suhara


Book ID
107614013
Publisher
Springer Japan
Year
2007
Tongue
English
Weight
298 KB
Volume
21
Category
Article
ISSN
0914-7187

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Nimodipine, an antagonist of the L-type calcium ion channel, was labelled with 11C for in vivo positron emission tomography studies of dihydropyridine binding in the human brain. The synthesis was based on esterification of the corresponding acid (W2100) using [2-11C]isopropyl iodide as the labellin