Mapping genetic systems by the supratype method

✍ Scribed by N. E. Morton; R. Lew

• Book ID: 104696949
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 450 KB
• Volume: 70
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00273447

✦ Synopsis

Kinship mapping and population supratypes provide information on order and relative genetic position of loci within a system too small to map by recombination. These methods are compared for the RH, beta-globin, HLA, and GM systems, where recombination between loci is estimated as 0.0002-0.0069. Supratype analysis does not appreciably improve kinship mapping. Mean recombination within systems appears to be 10(-4) morgans/kb, an order of magnitude greater than the average for the whole genome. Possible implications of this discrepancy are discussed.