✦ LIBER ✦

MAP1B expression and microtubule stability in growing and regenerating axons

✍ Scribed by Gordon-Weeks, Phillip R.; Fischer, Itzhak

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 223 KB
Volume: 48
Category: Article
ISSN: 1059-910X
DOI: 10.1002/(sici)1097-0029(20000115)48:2<63::aid-jemt2>3.0.co;2-1

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✦ Synopsis

MAP1B is a microtubule-associated phosphoprotein that is particularly highly expressed in developing neurons. There is experimental evidence that it plays an important role in neuronal differentiation, especially the extension of axons and dendrites, but exactly what role is unclear. Recent experiments have shed light on the gene structure of MAP1B and identified some of the kinases that phosphorylate the protein. Implicit in these findings is the idea that MAP1B regulates the organisation of microtubules in neurites and is itself regulated in a complex way and at a number of levels. Microsc.

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