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Mannose-binding lectin polymorphisms and pulmonary outcome in premature neonates: a

✍ Scribed by Ettore Capoluongo; Giovanni Vento; Sandro Rocchetti; Emiliano Giardina; Paola Concolino; Cecilia Sinibaldi; Concetta Santonocito; Valentina Vendettuoli; Milena Tana; Chiara Tirone; Cecilia Zuppi; Costantino Romagnoli; Giuseppe Novelli; Bruno Giardina; Franco Ameglio


Publisher
Springer
Year
2007
Tongue
English
Weight
130 KB
Volume
33
Category
Article
ISSN
1432-1238

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Mannose-binding lectin (MBL) is a C-type lectin produced mainly by the liver that binds to a wide range of pathogens. Polymorphisms at the promoter and exon 1 of the MBL2 gene are responsible for low serum levels of MBL and have been associated with an increased risk of infections. We prospectively

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## Abstract ## Background Infection, immunity and genetic factors play roles in the development of coal worker's pneumoconiosis (CWP) and progressive massive fibrosis (PMF). We investigate whether the genetic polymorphisms of mannose‐binding lectin (MBL), one of the key molecules of innate immunit