Mannich Reactions of Pyrimidines. II. 2-Methylmercapto-4-methyl-6-hydroxypyrimidine and 2-Thio-6-methyluracil 1,2
β Scribed by Snyder, H. R.; Foster, Harold M.; Nussberger, Gustav A.
- Book ID
- 126135413
- Publisher
- American Chemical Society
- Year
- 1954
- Tongue
- English
- Weight
- 553 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0002-7863
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The structure of the radical reaction product between thiamine and 4-0x0-2,2,6,6tetramethylpiperidine-1-oxyl has been investigated by X-ray crystallographic analysis. This structure had already been proposed by means of Mass-spectrometry and various chemical reactions. 1) CL3
The enamine character of the CH2-C(lla)=N(ll) fragment in the title compounds was studied. Congxatmds I gave l-dimethylaminomethylene products $ after Vilsmeier reaction. The l-formyl derivatives, obtained by alkaline hydrolysis of 5, were isolated as enol tautome~s and were vea'y unstable in acid m