Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells
✍ Scribed by Harsharan S. Bhatia; Eduardo Candelario-Jalil; Antonio C. Pinheiro de Oliveira; Olumayokun A. Olajide; Gregorio Martínez-Sánchez; Bernd L. Fiebich
- Book ID
- 116178239
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 564 KB
- Volume
- 477
- Category
- Article
- ISSN
- 0003-9861
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Prostaglandins and nitric oxide (NO) are among the numerous substances released by activated microglial cells, the brain resident macrophages, and they mediate several important microglial functions. We have previously shown that cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), the two key
Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in t