Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas
✍ Scribed by Ting-Ying Fu; Yu-Yi Hou; Sau-Tung Chu; Ching-Feng Liu; Cheng-Hui Huang; Hung-Chih Chen; Michael Hsiao; Pei-Jung Lu; Jyh-Seng Wang; Luo-Ping Ger
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 469 KB
- Volume
- 33
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background
We investigated the relationship of the immunohistochemical expression status of manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase (GPx), and myeloperoxidase (MPO) in buccal mucosal squamous cell carcinoma (SCC) with clinicopathologic parameters and prognosis.
Methods
The expression status of MnSOD, GPx, catalase, and MPO was evaluated by immunohistochemistry in a series of 216 surgically resected buccal mucosal SCC specimens, using tissue microarray slides.
Results
MnSOD, GPx, catalase, and MPO were commonly expressed in buccal mucosal SCC. The high expression level of MnSOD was associated with better disease‐specific survival (p = .009), especially for patients in moderate or poor cell differentiation (p = .045), pathologic stage I (p = .002) and postoperative radiotherapy (p = .048). The high expression level of GPx was also correlated with better disease‐specific survival (p = .042), especially for patients in pathologic stage IV (p = .010) and postoperative radiotherapy (p = .018).
Conclusions
MnSOD and GPx are significant prognostic factors for favorable survival in patients with buccal mucosal SCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2011