Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart

✍ Scribed by Tom C.-C. Hu; Timothy F. Christian; Anthony H. Aletras; Joni L. Taylor; Alan P. Koretsky; Andrew E. Arai

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 299 KB
• Volume: 54
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20516

✦ Synopsis

Abstract

The ability of MnCl~2~ to enhance canine myocardium and to delineate ischemic areas is demonstrated. A dose–response curve was measured using T~1~ weighted images in 11 dogs. MnCl~2~ (36, 113, 360, and 3600 μmol) was infused over a period of 3 min. Signal intensity increased linearly with MnCl~2~ dose. At 113 μmol (∼10 μmol/kg) the steady‐state increase in intensity averaged 212 ± 34%. No significant physiologic effects due to the infused MnCl~2~ were detected except at the highest dose where there was a cardiac depressive effect. Ischemia was induced by occluding the left anterior descending coronary artery in 5 dogs. At an infused dose of 113 μmol, MnCl~2~ clearly demarcated the ischemic zone during coronary occlusion. Contrast enhancement in the ischemic zone was less than 30% compared with normal tissue (P < 0.03). In conclusion, the intracellular contrast agent MnCl~2~ enhances the canine heart and shows promise in detecting ischemia at doses that do not cause adverse cardiac effects. Magn Reson Med 54:196–200, 2005. Published 2005 Wiley‐Liss, Inc.