Management of recurrent gastrointestinal stromal tumors
โ Scribed by Joshua H. Winer; Chandrajit P. Raut
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 494 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0022-4790
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## Abstract Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm in the gastrointestinal tract and is associated with mutations of the __KIT__ or __PDGFRA__ gene. In addition, other genetic events are believed to be involved in GIST tumorigenesis. Cytogenetic aberrations as
## Abstract ## Background Over the past decade, gastrointestinal stromal tumours (GISTs) have served as a model for the application of tyrosine kinase inhibitors in the treatment of solid neoplasms. Operative and medical management of GISTs is rapidly evolving, but current guidelines appear restri
## BACKGROUND. Telomerase activity has been observed in 80 -90% of carcinomas derived from various organs. However, to the authors' knowledge this report is the first assessment of telomerase activity in gastrointestinal stromal tumors (GISTs). ## METHODS. Telomerase activity was analyzed by th