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Management of polycythaemia vera, essential thrombocythaemia and myelofibrosis with hydroxyurea

✍ Scribed by Eva Löfvenberg; Anders Wahlin

Book ID: 114790864
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 409 KB
Volume: 41
Category: Article
ISSN: 0902-4441
DOI: 10.1111/j.1600-0609.1988.tb00212.x

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In polycythemia Vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not a