Management of neurotropic low-grade B-cell lymphoma: Report of two cases

✍ Scribed by Allie Garcia-Serra; Nancy Price Mendenhall; Russell W. Hinerman; James W. Lynch Jr.; Raul C. Braylan; Anthony A. Mancuso

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 225 KB
• Volume: 25
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.10311

✦ Synopsis

Background:

Low-grade lymphomas do not commonly involve the central or peripheral nervous system.

Methods:

Case report and review of the literature of two cases of b-cell lymphoma of the extranodal marginal zone type involving the head and neck region with evidence of extensive neurotropism are detailed in this report.

Results:

One patient was initially seen with a mass in the temporalis muscle and the other with a masticator space mass. the clinical course was indolent in both cases, although associated imaging studies suggested a more aggressive tumor. both patients were treated with moderate-dose radiotherapy only. at the time of writing, one patient has no evidence of disease 6.5 years after treatment and the other at 6 months.

Conclusions:

This suggests that some marginal zone lymphomas exhibit a low-grade clinical course despite an aggressive radiographic pattern of perineural and neurotropic spread. this type of lymphoma might be effectively treated with moderate-dose radiotherapy.