Management of Lymphomas: A Case-Based Approach

✍ Scribed by Jasmine Zain, Larry W. Kwak (eds.)

• Publisher: Adis, Springer International Publishing
• Year: 2017
• Tongue: English
• Leaves: 258
• Edition: 1st ed. 2017
• Category: Library

✦ Synopsis

This book will provide an overview of how to manage patients with lymphoma in the format of a series of engaging case studies. Lymphomas are cancers that originate in the lymphatic system. There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. These lymphomas comprise various subtypes with prognosis and treatment depending on the stage and type of the cancer. Lymphoma is a major global health problem; non-Hodgkin lymphoma in particular is the tenth most common type of cancer worldwide. In response to this there have been a number of significant advances in the available treatment options for lymphoma with new breakthrough drugs being approved or registered for approval. In light of this, this case study book will be an extremely timely guide for all hematologists, oncologists, and healthcare professionals wishing to keep up-to-date with these recent developments. The format of this book is also particularly appealing as it offer readers a practical approach to the clinical management of patients with these conditions as suggested by leading physicians from the City of Hope National Medical Center in California, USA in an era of vast therapeutic development.

✦ Table of Contents

Content: Editor biographies
Abbreviations
1 Overview of lymphoma
References
2 Pathogenesis of lymphomas
Genetic alterations lead to development of lymphomas
Mechanisms of genetic alterations in B-cell lymphomas
Signaling pathways involved in development of B-cell lymphomas
B-cell receptor pathway
Toll-like receptor pathway
Notch signaling
Nuclear factor-kappa B pathway
G-protein coupled receptors
Mitogen-activated protein kinase signaling pathway
PI3k-AKT1-MTOR signaling pathway
Role of MYC In lymphomagenesis
Role of p53 and DNA repair pathways
Regulation of apoptosis. Impairment of differentiation to plasma cellsEpigenetic alterations
Host/tumor interaction
Pathogenesis of T-cell and natural killer cell lymphomas
Pathogenesis of Hodgkin lymphoma
Conclusions
References
3 Classification of Hodgkin and non- Hodgkin lymphoma
Introduction
Clinical features in lymphoma
Role of clinical features in the classification of lymphoma
Early lesions
New lymphoproliferative disorders with an indolent behavior
Large B-cell lymphomas
Peripheral T-cell lymphomas
Conclusion
References
CASE STUDY SECTION ONE
Indolent B-cell lymphomas. 4 Small B-cell lymphocytic lymphoma and chronic lymphocytic leukemiaCase presentation
Introduction and epidemiology
Work up and diagnosis
Immunophenotyping
Additional testing
Prognostic markers
Staging
Recommended treatment and discussion:
Treatment components (systemic)
Chemotherapy
Monoclonal antibodies
Targeted therapies
Immunomodulatory agents
Cellular therapeutics
Sequencing of systemic treatment
Frontline therapy, no del17p/TP53 mutations
Frontline therapy, del17p/TP53 mutations present
Relasped/refractory therapy
Management of associated conditions and complications. Autoimmune complicationsInfections
Richter's transformation
Conclusions
References
5 Follicular lymphoma
Case presentation
Epidemiology
Pathology
Clinical presentation
Staging
Prognosis
Treatment of limited stage follicular lymphoma
Treatment of advanced stage follicular lymphoma
Timing of treatment initiation
Single-agent rituximab
First-line chemoimmunotherapy
Maintenance rituximab
Surveillance following completion of treatment
Treatment of relapsed or refractory follicular lymphoma
Novel targeted agents for relapsed or refractory follicular lymphoma. Hematopoietic stem cell transplantation for follicular lymphomaAllogeneic stem cell transplantation for follicular lymphoma
Transformed follicular lymphoma
Novel agents under development and future directions
Case conclusion
References
6 Lymphoplasmacytic lymphoma in the era of next generation sequencing
Case presentation
Lymphoplasmacytic lymphoma
Work up, diagnosis, and treatment
Clinical and pathologic diagnosis of lymphoplasmacytic lymphoma
Molecular diagnostic features in the era of next generation sequencing
Treatment of primary and previously treated disease.

✦ Subjects

Lymphomas Diagnosis.;Lymphomas -- Treatment -- Congresses.;Lymphomas -- Diagnosis.;Lymphomas -- Treatment.