𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Management of laryngeal premalignant lesions in the netherlands

✍ Scribed by Stijn A.J.H.M. Fleskens; Jeroen A.W.M. van der Laak; Pieter J. Slootweg; Robert P. Takes


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
277 KB
Volume
120
Category
Article
ISSN
0023-852X

No coin nor oath required. For personal study only.

✦ Synopsis


Abstract

Objectives/Hypothesis:

To investigate the current clinical management of laryngeal mucosal premalignant lesions (LMPLs) among otorhinolaryngologists working in university hospitals (tertiary referral centers) and nonuniversity hospitals (secondary referral centers) in The Netherlands. Then to compare the investigated practice with the results published in the literature.

Study Design:

Cross‐sectional study.

Methods:

A survey was conducted to assess the management of LMPLs. The questionnaire consisted of a systematic series of figures representing the initial presentation of a patient with a leukoplakic lesion at 12 different anatomical locations. The study group consisted of otorhinolaryngologists at all eight tertiary referral centers in The Netherlands (n = 22) and a random selection of otorhinolaryngologists (n = 25) from secondary referral centers throughout the country.

Results:

Comparing the initial management (surgical excision versus biopsy) preferred by otorhinolaryngologists at tertiary referral centers with that preferred by those at secondary referral centers, significant differences were found for seven anatomical locations. Notable differences were observed concerning the treatment of glottic lesions and the management of mild to moderate dysplasia after biopsy. Among the different tertiary referral centers, no uniform preference in management was noticed.

Conclusions:

There are significant differences in the management of LPMLs between otorhinolaryngologists at tertiary and secondary referral centers, depending on the location and histopathology of the lesions. Consensus on and development of guidelines concerning the management of LMPLs could be useful to optimize the diagnosis, treatment, and follow‐up of these lesions. Laryngoscope, 2010


πŸ“œ SIMILAR VOLUMES


Premalignant lesions of the breast
✍ Charles W. Boone πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 68 KB πŸ‘ 1 views

## Premalignant Lesions of the Breast In this session the histological, clinical, and epidemiological features of proliferative lesions of the breast are presented. Dr. Roy Jensen describes the criteria of Dupont and Page for making the diagnosis of proliferative breast lesions. Dupont and Page us

Demonstration of multiple HPV types in l
✍ Azzimonti, Barbara; Hertel, Laura; Aluffi, Paolo; Pia, Francesco; Monga, Guido; πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 246 KB πŸ‘ 1 views

Recent evidence has shown that human papillomavirus (HPV) is involved in both the development of carcinoma and in premalignant mucosal lesions of the oral cavity. This study examined the relationship of HPV infection to some pathological features in precancerous lesions of the larynx, not examined e

Premalignant lesions in the upper aerodi
✍ Charles W. Boone πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 116 KB

In this session, morphological, biological, and some clinical characteristics of precancerous lesions of the upper aerodigestive tract are described, as are the results of some cancer detection screening studies. Dr. John D. Crissman distinguishes between keratinizing and non-keratinizing dysplasia.

Microsatellite instability as an indicat
✍ Iacopo Sardi; Alessandro Franchi; Luca De Campora; Giulio Cesare Passali; Oreste πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 172 KB

## Abstract ## Background. Microsatellite instability (MSI) is considered a novel marker of genetic instability, and preliminary studies have shown that it may provide useful information in assessing the risk of malignant progression in preinvasive lesions. ## Methods. We analyzed MSI in serial