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Management of extracolonic tumours in patients with Lynch syndrome

✍ Scribed by Jan J Koornstra; Marian JE Mourits; Rolf H Sijmons; Annemarie M Leliveld; Harry Hollema; Jan H Kleibeuker

Book ID: 117784953
Publisher: The Lancet
Year: 2009
Tongue: English
Weight: 314 KB
Volume: 10
Category: Article
ISSN: 1470-2045
DOI: 10.1016/s1470-2045(09)70041-5

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## Abstract Genetic mosaicism is the presence of genetically different cell populations within an individual and can be associated with a milder disease phenotype. We describe a somatic mosaicism in a Lynch syndrome patient with a __MLH1__ gene mutation (c.1050delA). Since she was the sister of a h