Management of advanced squamous cell carcinomas of the maxillary sinus

✍ Scribed by Shankar P. G. Giri; Eashwer K. Reddy; Linda S. Getner; Leela Krishnan; Stephen R. Smalley; Richard G. Evans

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 495 KB
• Volume: 69
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19920201)69:3<657::aid-cncr2820690310>3.0.co;2-7

✦ Synopsis

From 1970 to 1988,41 cases of advanced maxillary sinus cancers were treated at the University of Kansas Medical Center. Local control for the 37 evaluable patients was achieved in 21 (57%). Local control by radiation therapy alone was achieved in ten of 19 (53%) patients compared with eight of 14 (57%) treated with a combination of surgery and radiation therapy. A dose greater than 6500 cGy correlated with better local control in patients treated with radiation therapy alone. Neck node failure occurred in three of 35 (8%) patients when not electively treated. Neck metastasis either at presentation or at a later stage reduced survival. The overall absolute survival for the entire group at 5 years was 35%. A combination of preoperative radiation therapy and surgery is recommended for patients with advanced-stage maxillary sinus cancer. Radiation therapy is an equally good alternative for those who are not surgical candidates or refuse surgery. Cancer 3992; 69:657-661.

Maxillary sinus tumors are relatively rare. In the United States, about 200 cases are reported yearly.' Therefore, it is difficult for a single institution to have much experience in their management. Most of these tumors present with locally advanced disease. The methods of treatment advocated range from surgery to radiation therapy (RT) to a combination of both. There is no consensus regarding the optimal management of these tumors. We retrospectively reviewed our experience at the University of Kansas Medical Center to assess the results of various treatments.

Materials and Methods

Between 1970 and 1988, 41 cases of maxillary sinus tumors were seen at the University of Kansas Medical Center. There were 26 men and 15 women (age range,