Management of a Multidrug-Resistant Pseudomonas Aeruginosa Infected Total Knee Arthroplasty Using Colistin. A Case Report and Review of the Literature

✍ Scribed by Panayiotis J. Papagelopoulos; Andreas F. Mavrogenis; Efthymia Giannitsioti; Athanasios Kikilas; Kyriaki Kanellakopoulou; Panayotis N. Soucacos

• Book ID: 116256466
• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 196 KB
• Volume: 22
• Category: Article
• ISSN: 1532-8406
• DOI: 10.1016/j.arth.2006.05.006

✦ Synopsis

Multidrug-resistant infections present a serious clinical and therapeutical problem. Colistin is an old-used polymyxin with rather poor pharmacokinetic profile and a remarkable nephrotoxicity. However, the emergence of multidrug-resistant bacteria has recently led to the increased use of colistin as a potentially available therapy. This article presents a 75-year-old diabetic woman with an early onset total knee arthroplasty infection by a multidrug-resistant Pseudomonas aeruginosa bacterial isolate that was managed successfully with surgical removal of the knee prosthesis, antibiotic impregnated cement and intravenous administration of colistin for 6 weeks, and second stage revision knee surgery. Two years later, laboratory and imaging studies showed no evidence of recurrence of infection.