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Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats

โœ Scribed by Stephen S. Hecht; Abraham Rivenson; Shantu Amin; Jacek Krzeminski; Karam El-Bayoumy; Bandaru S. Reddy; Christine Kurtzke; Edmond J. La Voie


Book ID
116123568
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
492 KB
Volume
106
Category
Article
ISSN
0304-3835

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Racemic anti-benzo[c]phenanthrene-3,4-diol-I ,2-epoxide (BcPDE) is a powerful rat mammary carcinogen and a metabolite of benzo[c]phenanthrene, a polynuclear aromatic hydrocarbon found in the environment. In elucidating potential molecular mechanisms that may play a role in the development of BcPDE-i