Reduced metastasis of transgenic mammary
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Kasper Almholt; Leif R. Lund; JΓΈrgen Rygaard; Boye S. Nielsen; Keld DanΓΈ; John R
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Article
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2004
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John Wiley and Sons
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French
β 232 KB
A prominent phenotype of plasmin deficiency in mice is reduced metastasis in the MMTV-PymT transgenic breast cancer model. Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA deficiency alone significantly reduces metastasis