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Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

โœ Scribed by Daniel Cejka; Silvia Hayer; Birgit Niederreiter; Wolfgang Sieghart; Thorsten Fuereder; Jochen Zwerina; Georg Schett


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
532 KB
Volume
62
Category
Article
ISSN
0004-3591

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โœ Tanja C. A. Tolboom; Annette H. M. van der Helm-Van Mil; Rob G. H. H. Nelissen; ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 78 KB ๐Ÿ‘ 2 views

## Abstract ## Objective Rheumatoid arthritis (RA) is characterized by inflammation and destruction of synovial joints. Fibroblastโ€like synoviocytes (FLS) harvested from synovial tissue of patients with RA can invade normal human cartilage in severe combined immunodeficient (SCID) mice and Matrige