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Mammalian sex determination: joining pieces of the genetic puzzle

✍ Scribed by Rafael Jiménez; Miguel Burgos

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
50 KB
Volume
20
Category
Article
ISSN
0265-9247

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✦ Synopsis

Mammalian sex determination is controlled by the Y-linked gene SRY. Studies of sex-reversed patients and experimental data obtained with mice have identified other genes, such as DAX1, SOX9, SF1, and WT1, which take part in the process, and have suggested how these genes interact to determine the sex of a mammalian embryo. A recent paper in Nature by Swain et al. provides experimental data that basically confirm the previously proposed hypothesis that SRY acts by inhibiting the action of DSS/DAX1, which is a repressor of genes of the male pathway.

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In mammals, male sex determination, as well as spermatogenesis, is controlled by genes on the Y chromosome. Evolutionary comparisons may be used to detect and test candidate genes for these functions, under the hypothesis that the rapid evolution of the mammalian Y chromosome causes it to contain fe