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Mammalian SCAN Domain Dimer Is a Domain-Swapped Homolog of the HIV Capsid C-Terminal Domain

✍ Scribed by Dmitri Ivanov; James R. Stone; Jenny L. Maki; Tucker Collins; Gerhard Wagner

Book ID
116753755
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
273 KB
Volume
17
Category
Article
ISSN
1097-2765

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✍ Nan Zhong; Shengnan Zhang; Fei Xue; Xue Kang; Peng Zou; Jiaxuan Chen; Chao Liang πŸ“‚ Article πŸ“… 2009 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 431 KB

## Abstract SARS coronavirus main protease (M^pro^) plays an essential role in the extensive proteolytic processing of the viral polyproteins (pp1a and pp1ab), and it is an important target for anti‐SARS drug development. We have reported that both the M^pro^ C‐terminal domain alone (M^pro^‐C) and