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Mammalian meiosis involves DNA double-strand breaks with 3′ overhangs

✍ Scribed by Drora Zenvirth; Carmelit Richler; Amit Bardhan; Frédéric Baudat; Ari Barzilai; Jacob Wahrman; Giora Simchen


Book ID
106089794
Publisher
Springer
Year
2003
Tongue
English
Weight
280 KB
Volume
111
Category
Article
ISSN
0009-5915

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## Abstract DNA double‐strand breaks (DSBs) are extremely hazardous lesions for all DNA‐bearing organisms and the mechanisms of DSB repair are highly conserved. In the eukaryotic mitotic cell cycle, DSBs are often present following DNA replication while, in meiosis, hundreds of DSBs are generated a